Several experiments on animal models have shown that the amino acid glycine acts as a modulator in the systemic inflammatory cascade. Also revealing benefits on microcirculation. Thus determining an increase in the count of monocytes in the intestinal anastomosis.
The protective effect of glycine.
Against oxidative damage caused by intestinal ischemia/reperfusion, this protective effect has been demonstrated in several studies.
In rats subjected to glycine supplementation by abdominal irradiation, preservation of colonic wall thickness and morphology occurred.
A reduction and/or absence of colitis (which was experimentally induced) was observed with the intake of glycine through the diet.
The result highlights a possible beneficial effect of glycine supplementation in inflammatory bowel diseases.
Experimental evidence suggests that glycine absorbed through the intestinal epithelium (GLYT1 carrier-mediated absorption) is used for the protection of epithelial cells.
In addition to maintaining the intracellular antioxidant potential.
Glutamine in the human body.
Glutamine is an amino acid , the most abundant in our body. It plays an important role in protecting the physiological immune and gastrointestinal function.
It has recently been demonstrated that chronic glutamine supplementation can perform two beneficial activities under conditions of intense physical exercise:
- prevents exercise-induced gastrointestinal permeability through stabilization of epithelial tight-junctions
- suppression/inhibition of NF-kB (protein complex functioning as a transcription factor) essential in the pro-inflammatory pathway in peripheral blood mononuclear cells
A possible cause of some subtypes of irritable colon could just be an increased intestinal permeability. This determines the passage of harmful substances, bacteria, toxins, through the intestinal mucosa.
Glutamine is useful in creating a barrier for the intestinal mucosa, so its deficiency would cause the passage of harmful substances.